Pdf on oct 31, 2018, chinmaya keshari sahoo and others published formulation and optimization of controlled porosity osmotic pump. Asian journal of pharmaceutics octdec 2016 10 4 287 formulation and optimization of controlled porosity osmotic pump tablet for oral administration of glipizide s. Absolute and effective porosity of petroleum reservoirs. A new strength model based on watercement ratio and. Lin 4 1 lecturer, civil engineering department, chengshiu institute of technology, kaohsiung, taiwan. In this study, osmotic drug delivery matrix tablets of losartan potassium were developed. There is achance of dose dumping if the coating process is not well controlled. Jul 31, 2015 procedure 1 record the temperature in the laboratory.
Porosity and pore area determination of hollow fiber. Typical ranges of porosity of source rocks for petroleum drilling are between 5% and 25% as seen in fig. A system that can deliver drug at a controlled rate is very important for the treatment of various chronic diseases such as diabetes, asthma, and heart disease. A boxbehnken experimental design was applied to optimize the parameters for cpop. Asian journal of research in chemistry and pharmaceutical. Therefore, there was a need to modulate the solubility of the drug using suitable. Measuring the osmotic water permeability coefficient pf. Poorly watersoluble drug with phdependent solubility such as gliclazide glz offers challenges in the controlledrelease formulation because of low dissolution rate and poor bioavailability. Review on controlled porosity osmotic pump tablets and its basic. The present study aimed to prepare, optimize, and evaluate tapentadol hydrochloride controlled porosity osmotic pump cpop and to achieve the drug release at nearly zeroorder.
This example problem demonstrates how to calculate the amount of solute to add to create a specific osmotic pressure in a solution. Osmotic system releases a drug at a predetermined zero order delivery rate based on osmosis. Osmotic pressure also reflects how readily water can enter the solution via osmosis, as across a cell membrane. Formulation and evaluation of controlled porosity osmotic pump for oral delivery of ketorolac abstract background. Formulation and optimization of controlled porosity. Effervescent elementary osmotic pump modified osmotic pump 1.
The core tablets of losartan potassium consisted of drug along with an osmotic agent mannitol and swellable polymer hydroxy propyl methylcellulose710 methocel. Controlled porosity osmotic pump cpop controlled porosity osmotic pump is an osmotic tablet in which membrane contains water soluble leachable pore forming agents. Osmotic pump, osmotic pressure, pore forming agent, osmogen, wicking agent. The total concentration difference between inside and out is. May 10, 2019 todd helmenstine is a science writer and illustrator who has taught physics and math at the college level. July september 9 the unique feature of semipermeable membrane utilized for an osmotic pump is that it permits. He holds bachelors degrees in both physics and mathematics. Controlled porosity osmotic pumpbased controlled release. Then, controlled porosity osmotic pump cpop tablet of gliclazide was designed to deliver drug in a controlled manner up to 16 h.
Optimization and development of swellable controlled. The controlled porosity osmotic pump has been developed via incorporation of leachable watersoluble small molecules, such as sodium chloride, potassium chloride, urea, and sucrose etc. Captopril, osmotic tablets, controlled release design and development of controlled porosity osmotic tablets of captopril article history. Controlled porosity osmotic pump cpop contains drug, osmogens, excipients in core and a coating of semipermeable membrane with water soluble additives. The instant invention is directed to an osmotic pump comprising. This video shows the parts of the pump and describes how the pump operates to enable continuous delivery. However, the drawback of this potentially useful hypoglycemic agent is that it is highly hydrophobic and practically insoluble in water. Dec 17, 2015 the present study aimed to prepare, optimize, and evaluate tapentadol hydrochloride controlled porosity osmotic pump cpop and to achieve the drug release at nearly zeroorder. The coating of semi permeable membrane is done by a suitable coating method. How much glucose c 6 h 12 o 6 per liter should be used for an intravenous solution to match the 7. Ebscohost serves thousands of libraries with premium essays, articles and other content including controlledporosity osmotic pump tabletsan overview.
One application of this is removing liquid flooding water from channels and gas diffusion layers and direct hydration of the proton exchange membrane in the membrane electrode assembly mea of the proton exchange membrane fuel cells. Optimization and development of swellable controlled porosity. Rezaei dashtarzhandi, cmehdi abbasgholipourghadim, ashahab khademi afaculty of mechanical engineering, badvanced membrane technology. Studied a controlled porosity osmotic pump based drug delivery system. Swellable, controlled porosity, osmotic pump tablet, taguchi orthogonal design, fraction. Controlled porosity osmotic pump cpop based drug delivery system contains active ingredient, osmogens, semi permeable membrane. Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent mahalaxmi. Formulation and evaluation of controlled porosity osmotic. The effect of matric and osmotic potential of soil r.
The cpop was prepared by the coating of polymers eudragit rspo and rlpo on a directly compressed core tablet. The aim of the current study was to design a controlled porosity osmotic pump cpopbased drug delivery system for controlled release of an nsaid agent, ketorolac tromethamine, which is expected to improve patient compliance due to reduced frequency. Controlled porosity osmotic pump tablets thesis writing. R1, phanidhar sastri1, ravikumar3, atin kalra1, pritam kanagale. Osmotic drug delivery using swellablecore technology. Water will flow from one solution to another, trying to create equilibrium between both solutions. Osmotic pressure is the pressure that stops the process of. Design and development of controlled porosity osmotic tablets. Osmosis is the flow of a solvent into a solution through a semipermeable membrane. Formulation and evaluation of osmotic pump delivery of. Porosity and pore area determination of hollow fiber membrane incorporating digital image processing amohammad abbasgholipourghadim,amusa mailah, aintan zaurah mat darus, ba. The socalled osmotic effective area is the area contacted by the osmotic substances. A boxbehnken experimental design was applied to optimize.
The osmotic drug delivery systems suitable for oral administration typically consist of a compressed tablet core that is coated with a semipermeable membrane that has an oriice drilled on it by means of a laser beam or mechanical. Osmotic blistering is a chemical phenomenon where two substances attempt to reach equilibrium through a semipermeable membrane overview. Design and development of controlled porosity osmotic. Some of the investigators have also studied the role of parameters like coating, release retardants etc. Unlike the elementary osmotic pump eop which consists of an osmotic core with the drug surrounded by a semipermeable membrane drilled with a delivery orifice, controlled porosity of the membrane. To date, several methods have been employed in measuring the endogenous p f of protoplast from different plant organs i. Sem showed the formation of pores in the membrane through which drug release occurred. The core tablets were coated with ethyl cellulose 7. Lornoxicam release from controlled porosity osmotic pump was directly proportional to the pore former sorbitol and level of osmogen mannitol. Although controlled porosity osmotic pump tablet could be prepared simply, they were usually applicable for soluble drugs. Preparation of controlled porosity osmotic pump tablets for. Pdf a novel controlled porosity osmotic pump system for.
Elementary osmotic pump delivers 6080% of its contents at a constant rate, and there is a short lag time of 3060 min as the system hydrates before zero order delivery from the elementary osmotic pump is obtained. The porous osmotic pump contains pore forming water soluble additives in the coating. The instant invention is directed to an osmotic pump, for the controlled release of diltiazem lmalate to an environment of use, said pump comprising. Enhancement of dissolution of glipizide from controlled. Development and evaluation of a oncedaily controlled. Studied a controlled porosity osmotic pumpbased drug delivery system. The surface porosity of fabricated membranes were calculated by the following equation. The osmotic pressure of a solution is the minimum amount of pressure needed to prevent water from flowing into it across a semipermeable membrane. A new strength model based on watercement ratio and capillary porosity k.
Controlled porosity solubility modulated osmotic pump tablets. Conclusion a porous osmotic pumpbased drug delivery system can. Drug release from the developed formulations was independent of ph and agitational intensity and was dependent on. Formulation and optimization of controlled porosity osmotic. The developed formulation was optimized for type and level of. Osmotic pressure is the pressure that stops the process of osmosis. Controlled porosity solubility modulated osmotic pump.
Subcutaneous angiotensin ii infusion using osmotic pumps. Preparation of controlled porosity osmotic pump tablets for salvianolic acid and optimization of the formulation using an artificial neural network method. Aug 20, 2018 what is the osmotic pressure of a solution prepared by adding. Procedure 1 record the temperature in the laboratory. Development of controlled porosity osmotic pump of. A significant milestone in oral ndds is osmotic drug delivery system. Poorly watersoluble drug with phdependent solubility such as gliclazide glz offers challenges in the controlled release formulation because of low dissolution rate and poor bioavailability. Porosity determination by liquid saturation method. L oros hard cap, l oros soft cap and delayed liquid bolus delivery system, telescopic capsule, 23 oros ct, 24 sandwiched osmotic. The coating composition of cpop includes pore forming. Apr 29, 2012 a modified twolayered, pushpull osmotic system was developed by using the basic designs of various oral osmotic pumps, such as controlled porosity osmotic pump cpop, elementary osmotic pump eop and pushpull osmotic pump ppop.
Pump back was conducted at the rate of 60 gpm, with the pump set 15 ft above the bottom of the aquifer. It is therefore possible to cal culate the osmotic pressure of a given solution, first, on the assumption that vant hoffs law is correct, and second, on. For concreteness the mechanism is discussed in the context of a. Recent patent in controlled porosity osmotic pump request pdf. An electroosmotic pump eop, or eo pump, is used for generating flow or pressure by use of an electric field. Formulation and evaluation of osmotic pump delivery of oxybutynin. For a dilute solution, osmotic pressure obeys a form of the ideal gas law and can be. The controlled porosity osmotic pump sciencedirect. Also, the preparation of swellable controlled porosity osmotic pump tablet was facilitated by coating the core tablet with pore forming agent, thus eliminating the need for the more expensive laser drilling. The delivery system of drug comprises a core with the drug surrounded by semi permeable membrane. This finding confirms that the mechanism of drug release is by the osmotic pressure. Recent advances include various specific types of osmotic pump systems such as controlled porosity osmotic pump 20 cpop, osmotic bursting osmotic pump 21 obop, liquid orosliquid oral osmotic system 22 e.
Effective porosity determination by helium porosimeter method exp. Membrane surface porosity and pore area distribution. Drug release from the developed formulations was independent of ph and agitational intensity and was dependent on osmotic pressure of the release media. The porous osmotic pump based drug delivery system for excellent controlled release of drug for 24 hrs. Usually, the two solutions are concrete and the coating application on top of the concrete. Ebscohost serves thousands of libraries with premium essays, articles and other content including controlled porosity osmotic pump tabletsan overview.
Controlled porosity osmotic pump tablet cpop system was designed to. A modified twolayered, pushpull osmotic system was developed by using the basic designs of various oral osmotic pumps, such as controlled porosity osmotic pump cpop, elementary osmotic pump eop and pushpull osmotic pump. A at least one active agent surrounded by b a rate controlling water insoluble wall, having a fluid permeability of 6. Calculating osmotic pressure with an example problem. Background a system that can deliver multidrug at a prolonged rate is very important for the treatment of various chronic diseases such as diabetes, asthma and heart disease. Disouza3 1department of pharmaceutics, sant gajanan maharaj college of pharmacy, mahagaon, gadhinglaj. Received 25 aug 20 accepted 10 sept 20 available online sept 20 as dose, absorption rate constant, elimination rate constant, metabolic properties. Apr 14, 2003 a controlled porosity osmotic pump based drug delivery system has been described in this study.
Received 25 aug 20 accepted 10 sept 20 available online sept 20 as dose, absorption rate constant, elimination rate constant, metabolic properties, for correspondence. Unlike the elementary osmotic pump eop which consists of an osmotic core with the drug surrounded by a semipermeable membrane drilled with a delivery orifice, controlled porosity of the membrane is accomplished by the use of different channeling. Development and evaluation of controlled porosity osmotic. Pdf formulation and optimization of controlled porosity osmotic. At the cellular level, aquaporins aqps play a key role in the regulation of the osmotic water permeability coefficient p f of the cell membrane. A novel controlled porosity osmotic pump system for sodium ferulate article pdf available in pharmazie 6112.
Formulation and optimization of controlled porosity osmotic pump. Therefore, the equal amounts of atmospheric pressures on the two sides of the membrane cannot be ignored, or cancelled out. The osmotic pump of claim 7, wherein at least 1 microgram of active agent is used. Formulation and evaluation of oral controlled release osmotic. Formulation aspects in development of controlled porosity. Review on controlled porosity osmotic pump tablets and its. Asian journal of research in chemistry and pharmaceutical sciences. In the present investigation, controlled porosity osmotic pump cpop system of glipizide gz was developed since preparation of cpop is simple. Formulation and evaluation of losartan potassium osmotic. A controlled porosity osmotic pumpbased drug delivery system has been described in this study. The osmotic pressure is a colligative property of a solution in which the magnitude of. A a core which comprises a therapeutically effective amount of diltiazem lmalate and an effective buffering amount of sodium bitartrate surrounded by b a rate controlling water insoluble wall, having a fluid permeability of 6.
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