Procedure 1 record the temperature in the laboratory. Sem showed the formation of pores in the membrane through which drug release occurred. A new strength model based on watercement ratio and. Optimization and development of swellable controlled. Formulation and evaluation of controlled porosity osmotic pump for oral delivery of ketorolac abstract background. Osmotic blistering is a chemical phenomenon where two substances attempt to reach equilibrium through a semipermeable membrane overview. The porous osmotic pump contains pore forming water soluble additives in the coating. A modified twolayered, pushpull osmotic system was developed by using the basic designs of various oral osmotic pumps, such as controlled porosity osmotic pump cpop, elementary osmotic pump eop and pushpull osmotic pump.
Pump back was conducted at the rate of 60 gpm, with the pump set 15 ft above the bottom of the aquifer. The core tablets of losartan potassium consisted of drug along with an osmotic agent mannitol and swellable polymer hydroxy propyl methylcellulose710 methocel. Calculating osmotic pressure with an example problem. The surface porosity of fabricated membranes were calculated by the following equation. Formulation and optimization of controlled porosity osmotic pump. Rezaei dashtarzhandi, cmehdi abbasgholipourghadim, ashahab khademi afaculty of mechanical engineering, badvanced membrane technology. Design and development of controlled porosity osmotic. Recent advances include various specific types of osmotic pump systems such as controlled porosity osmotic pump 20 cpop, osmotic bursting osmotic pump 21 obop, liquid orosliquid oral osmotic system 22 e.
Effective porosity determination by helium porosimeter method exp. Unlike the elementary osmotic pump eop which consists of an osmotic core with the drug surrounded by a semipermeable membrane drilled with a delivery orifice, controlled porosity of the membrane. A boxbehnken experimental design was applied to optimize the parameters for cpop. One application of this is removing liquid flooding water from channels and gas diffusion layers and direct hydration of the proton exchange membrane in the membrane electrode assembly mea of the proton exchange membrane fuel cells. Formulation and evaluation of oral controlled release osmotic. Captopril, osmotic tablets, controlled release design and development of controlled porosity osmotic tablets of captopril article history. Preparation of controlled porosity osmotic pump tablets for salvianolic acid and optimization of the formulation using an artificial neural network method. Drug release from the developed formulations was independent of ph and agitational intensity and was dependent on osmotic pressure of the release media. The total concentration difference between inside and out is. Controlled porosity solubility modulated osmotic pump.
At the cellular level, aquaporins aqps play a key role in the regulation of the osmotic water permeability coefficient p f of the cell membrane. Asian journal of pharmaceutics octdec 2016 10 4 287 formulation and optimization of controlled porosity osmotic pump tablet for oral administration of glipizide s. Pdf formulation and optimization of controlled porosity osmotic. Typical ranges of porosity of source rocks for petroleum drilling are between 5% and 25% as seen in fig. Ebscohost serves thousands of libraries with premium essays, articles and other content including controlledporosity osmotic pump tabletsan overview. Controlled porosity osmotic pump cpop controlled porosity osmotic pump is an osmotic tablet in which membrane contains water soluble leachable pore forming agents. Optimization and development of swellable controlled porosity. It is therefore possible to cal culate the osmotic pressure of a given solution, first, on the assumption that vant hoffs law is correct, and second, on. The developed formulation was optimized for type and level of. For a dilute solution, osmotic pressure obeys a form of the ideal gas law and can be. Also, the preparation of swellable controlled porosity osmotic pump tablet was facilitated by coating the core tablet with pore forming agent, thus eliminating the. Asian journal of research in chemistry and pharmaceutical sciences.
The porous osmotic pump based drug delivery system for excellent controlled release of drug for 24 hrs. Osmotic drug delivery using swellablecore technology. Preparation of controlled porosity osmotic pump tablets for. Osmotic system releases a drug at a predetermined zero order delivery rate based on osmosis. This finding confirms that the mechanism of drug release is by the osmotic pressure.
Controlled porosity osmotic pump tablet cpop system was designed to. The cpop was prepared by the coating of polymers eudragit rspo and rlpo on a directly compressed core tablet. The osmotic pump of claim 5 wherein said wall is 20 to 500 microns thick and said wall pores are between 10 angstroms and 25 microns in diameter. Controlled porosity osmotic pump cpop contains drug, osmogens, excipients in core and a coating of semipermeable membrane with water soluble additives. The osmotic pressure is a colligative property of a solution in which the magnitude of. There is achance of dose dumping if the coating process is not well controlled. Lornoxicam release from controlled porosity osmotic pump was directly proportional to the pore former sorbitol and level of osmogen mannitol. Pdf a novel controlled porosity osmotic pump system for. Poorly watersoluble drug with phdependent solubility such as gliclazide glz offers challenges in the controlledrelease formulation because of low dissolution rate and poor bioavailability. Development and evaluation of a oncedaily controlled. A controlled porosity osmotic pumpbased drug delivery system has been described in this study. Apr 29, 2012 a modified twolayered, pushpull osmotic system was developed by using the basic designs of various oral osmotic pumps, such as controlled porosity osmotic pump cpop, elementary osmotic pump eop and pushpull osmotic pump ppop. Therefore, the equal amounts of atmospheric pressures on the two sides of the membrane cannot be ignored, or cancelled out. July september 9 the unique feature of semipermeable membrane utilized for an osmotic pump is that it permits.
The present study aimed to prepare, optimize, and evaluate tapentadol hydrochloride controlled porosity osmotic pump cpop and to achieve the drug release at nearly zeroorder. Development of controlled porosity osmotic pump of. Formulation and evaluation of oral controlled release. Studied a controlled porosity osmotic pump based drug delivery system. Formulation and evaluation of controlled porosity osmotic pump for. Then, controlled porosity osmotic pump cpop tablet of gliclazide was designed to deliver drug in a controlled manner up to 16 h.
Received 25 aug 20 accepted 10 sept 20 available online sept 20 as dose, absorption rate constant, elimination rate constant, metabolic properties, for correspondence. Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent mahalaxmi. Development of controlled porosity osmotic pump of metoprolol. The osmotic drug delivery systems suitable for oral administration typically consist of a compressed tablet core that is coated with a semipermeable membrane that has an oriice drilled on it by means of a laser beam or mechanical. Apr 14, 2003 a controlled porosity osmotic pump based drug delivery system has been described in this study. The effect of matric and osmotic potential of soil r. The coating of semi permeable membrane is done by a suitable coating method. Controlled porosity osmotic pump tablets thesis writing.
Formulation aspects in development of controlled porosity. Jul 31, 2015 procedure 1 record the temperature in the laboratory. Alzet pumps deliver by the process of osmotic displacement. Elementary osmotic pump delivers 6080% of its contents at a constant rate, and there is a short lag time of 3060 min as the system hydrates before zero order delivery from the elementary osmotic pump is obtained. Porosity determination by liquid saturation method. A new strength model based on watercement ratio and capillary porosity k. Osmosis is the flow of a solvent into a solution through a semipermeable membrane. The aim of the current study was to design a controlled porosity osmotic pump cpopbased drug delivery system for controlled release of an nsaid agent, ketorolac tromethamine, which is expected to improve patient compliance due to reduced frequency. R1, phanidhar sastri1, ravikumar3, atin kalra1, pritam kanagale. Effervescent elementary osmotic pump modified osmotic pump 1. Development and evaluation of controlled porosity osmotic. In the present investigation, controlled porosity osmotic pump cpop system of glipizide gz was developed since preparation of cpop is simple. This video shows the parts of the pump and describes how the pump operates to enable continuous delivery. To date, several methods have been employed in measuring the endogenous p f of protoplast from different plant organs i.
The resulting spongelike structures formed the controlled porosity walls of interest and were substan tially permeable to both water and dissolved drug agents. Swellable, controlled porosity, osmotic pump tablet, taguchi orthogonal design, fraction. The controlled porosity osmotic pump sciencedirect. Poorly watersoluble drug with phdependent solubility such as gliclazide glz offers challenges in the controlled release formulation because of low dissolution rate and poor bioavailability. The core tablets were coated with ethyl cellulose 7. Lin 4 1 lecturer, civil engineering department, chengshiu institute of technology, kaohsiung, taiwan. Formulation and optimization of controlled porosity. The controlled porosity osmotic pump has been developed via incorporation of leachable watersoluble small molecules, such as sodium chloride, potassium chloride, urea, and sucrose etc. Some of the investigators have also studied the role of parameters like coating, release retardants etc. Received 25 aug 20 accepted 10 sept 20 available online sept 20 as dose, absorption rate constant, elimination rate constant, metabolic properties. Membrane surface porosity and pore area distribution. The osmotic pressure of a solution is the minimum amount of pressure needed to prevent water from flowing into it across a semipermeable membrane. Controlled porosity osmotic pump cpop based drug delivery system contains active ingredient, osmogens, semi permeable membrane. Pdf on oct 31, 2018, chinmaya keshari sahoo and others published formulation and optimization of controlled porosity osmotic pump.
Porosity and pore area determination of hollow fiber membrane incorporating digital image processing amohammad abbasgholipourghadim,amusa mailah, aintan zaurah mat darus, ba. Absolute and effective porosity of petroleum reservoirs. A a core which comprises a therapeutically effective amount of diltiazem lmalate and an effective buffering amount of sodium bitartrate surrounded by b a rate controlling water insoluble wall, having a fluid permeability of 6. The instant invention is directed to an osmotic pump comprising. Dec 17, 2015 the present study aimed to prepare, optimize, and evaluate tapentadol hydrochloride controlled porosity osmotic pump cpop and to achieve the drug release at nearly zeroorder. L oros hard cap, l oros soft cap and delayed liquid bolus delivery system, telescopic capsule, 23 oros ct, 24 sandwiched osmotic. Asian journal of research in chemistry and pharmaceutical. Although controlled porosity osmotic pump tablet could be prepared simply, they were usually applicable for soluble drugs. Controlled porosity solubility modulated osmotic pump tablets. Therefore, there was a need to modulate the solubility of the drug using suitable. Review on controlled porosity osmotic pump tablets and its basic. Design and development of controlled porosity osmotic tablets. A significant milestone in oral ndds is osmotic drug delivery system.
At this pumping rate, maximum drawdown at the test well was not more than about 5 ft, or 10% of the saturated thickness of the aquifer. A system that can deliver drug at a controlled rate is very important for the treatment of various chronic diseases such as diabetes, asthma, and heart disease. The osmotic pump of claim 7, wherein at least 1 microgram of active agent is used. Osmotic pressure also reflects how readily water can enter the solution via osmosis, as across a cell membrane. A at least one active agent surrounded by b a rate controlling water insoluble wall, having a fluid permeability of 6. Formulation and evaluation of losartan potassium osmotic. Unlike the elementary osmotic pump eop which consists of an osmotic core with the drug surrounded by a semipermeable membrane drilled with a delivery orifice, controlled porosity of the membrane is accomplished by the use of different channeling. How much glucose c 6 h 12 o 6 per liter should be used for an intravenous solution to match the 7. May 10, 2019 todd helmenstine is a science writer and illustrator who has taught physics and math at the college level.
Osmotic pump for insoluble drugs multi chamber osmotic. An electroosmotic pump eop, or eo pump, is used for generating flow or pressure by use of an electric field. For concreteness the mechanism is discussed in the context of a. He holds bachelors degrees in both physics and mathematics. Drug release from the developed formulations was independent of ph and agitational intensity and was dependent on. Us4880631a us07100,665 us10066587a us4880631a us 4880631 a us4880631 a us 4880631a us 10066587 a us10066587 a us 10066587a us 4880631 a us4880631 a us 4880631a authority us united states prior art keywords osmotic pump pump according wall malate diltiazem prior art date 19870924 legal status the legal status is an assumption and. A boxbehnken experimental design was applied to optimize. The coating composition of cpop includes pore forming. Enhancement of dissolution of glipizide from controlled. In this study, osmotic drug delivery matrix tablets of losartan potassium were developed. Osmotic pump, osmotic pressure, pore forming agent, osmogen, wicking agent.
Controlled porosity osmotic pumpbased controlled release. Usually, the two solutions are concrete and the coating application on top of the concrete. Conclusion a porous osmotic pumpbased drug delivery system can. Formulation and optimization of controlled porosity osmotic. The socalled osmotic effective area is the area contacted by the osmotic substances. Porosity and pore area determination of hollow fiber. This example problem demonstrates how to calculate the amount of solute to add to create a specific osmotic pressure in a solution. The controlledporosity osmotic pump has been developed via incorporation of leachable watersoluble small molecules, such as sodium chloride, potassium chloride, urea, and sucrose etc.
Formulation and evaluation of controlled porosity osmotic. However, the drawback of this potentially useful hypoglycemic agent is that it is highly hydrophobic and practically insoluble in water. The instant invention is directed to an osmotic pump, for the controlled release of diltiazem lmalate to an environment of use, said pump comprising. Subcutaneous angiotensin ii infusion using osmotic pumps. Measuring the osmotic water permeability coefficient pf. Formulation and evaluation of osmotic pump delivery of oxybutynin. Osmotic pressure is the pressure that stops the process of osmosis. Water will flow from one solution to another, trying to create equilibrium between both solutions.
Aug 20, 2018 what is the osmotic pressure of a solution prepared by adding. Osmotic pressure is the pressure that stops the process of. Formulation and evaluation of osmotic pump delivery of. Background a system that can deliver multidrug at a prolonged rate is very important for the treatment of various chronic diseases such as diabetes, asthma and heart disease. Also, the preparation of swellable controlled porosity osmotic pump tablet was facilitated by coating the core tablet with pore forming agent, thus eliminating the need for the more expensive laser drilling. A novel controlled porosity osmotic pump system for sodium ferulate article pdf available in pharmazie 6112. Ebscohost serves thousands of libraries with premium essays, articles and other content including controlled porosity osmotic pump tabletsan overview. Disouza3 1department of pharmaceutics, sant gajanan maharaj college of pharmacy, mahagaon, gadhinglaj. After filling the pump body with angii, the flow moderator is inserted to seal the pump. Recent patent in controlled porosity osmotic pump request pdf. Studied a controlled porosity osmotic pumpbased drug delivery system.
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